MUTANTS OF RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEINS

Abstract: the present disclosure relates to the field of biomedicine, and in particular, to an improved mutant of a respiratory syncytial virus (rsv) fusion (f) protein and uses thereof. the mutant can form a trimeric structure without introducing a heterologous trimerization domain. meanwhile, through mutation designs such as releasing internal electrostatic repulsion, deleting the furin cleavage site, truncating the c-terminal domain, and introducing interchain disulfide bonds, the protein is stabilized in the pre-fusion conformation and exhibits enhanced stability. the mutant in the present disclosure is highly immunogenic when used as a vaccine or a vaccine component and can induce the production of a high level of neutralizing antibodies in the immunized animal, which can be used in the preparation of a vaccine for the prevention or treatment of rsv infection, and can also be used as a reagent for the detection of rsv.

Inventor(s): Lei CHEN, Yujiao SONG, Min DAI, Xin XIE, Shibi ZHAO, Jiahao XU, Yujuan HUA, Chao WU, Sufang GU, Tao FANG, Li CHEN, Jiadi HUANG, Xiaoya DING, Mingze SHI, Peizhe LI, Jiaxin LEI, Guangsha ZHANG, Meng ZHANG, Wendie WANG, Ruihong JIANG, Songming HE, Derong WANG, Tengsen GAO, Eric CHEN, Jianguo YIN

CPC Classification: A61K39/155 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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