CGAS SUPER-ENZYMES FOR CANCER IMMUNOTHERAPY

Abstract: the present invention relates to anti-tumor lymphocytes, and a variant cyclic gmp-amp synthase (cgas) carrying an amino acid substitution of one or both arginines at amino acid positions 255 and 236 and/or an amino acid substitution of one or both lysines at amino acid positions 254 and 258; or a nucleic acid molecule encoding said variant cgas for use in the treatment of a tumor in a subject.

Inventor(s): Andrea ABLASSER, Natasha SAMSON, Alexander KELLER

CPC Classification: A61K38/45 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

Search for rejections for patent application number 20250205314