ADJUNCTIVE TREATMENT OF MYCOBACTERIAL DISEASES

Abstract: disclosed herein are azidodeoxy- and aminodeoxy trehalose (treaz and trenh) compounds that inhibit (an etiological agent of tb) biofilm (an in vitro model of intent tb infection) formation via blocking of the adaptive strategy used by form biofilm, termed trehalose catalytic shift. prior to our work, such compounds were never tested for inhibition of mycobacterial biofilm formation. our work defined this class of compounds' mechanism of action and showed for the first time that they sensitize drug-tolerant mycobacteria to existing clinically used antibiotics. the disclosed compounds are potential drugs for adjunctive treatment of tb and related mycobacterial diseases.

Inventor(s): Hyungjin EOH, Benjamin SWARTS, Peter WOODRUFF, Jae Jin LEE

CPC Classification: A61K31/7016 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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