ENGINEERED EXTRACELLULAR VESICLES FOR TARGETED DRUG DELIVERY TO MUSCLE

Abstract: the invention relates to myotropic extracellular vesicle compositions comprising a muscle-targeting membrane protein and optionally one or more therapeutic agents. the invention further relates to methods of using the myotropic extracellular vesicles comprising a muscle-targeting membrane protein for therapeutic applications for treating muscular disorders, conditions, and damage in a subject.

Inventor(s): Kyle Shuler, Andrew Mitchell, Eric Muñoz, John Sperduto, Matthew Hudson

CPC Classification: A61K9/5068 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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