BIODEGRADABLE LIPIDS AND FORMULATIONS FOR DELIVERY OF MRNA

Abstract: provided herein are compounds, such as compounds of formulae (i), (i′), (xi), (xii), and (xiii), and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. the compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mrna, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). also provided herein are methods of synthesis of compounds of formulae (i′), (xi), (xii), (xiii), and (viii).

Inventor(s): Daniel Griffith Anderson, Arnab Rudra, Akash Gupta, Kaelan Reed

CPC Classification: A61K9/1272 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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