SYSTEMS AND METHODS FOR NORMOTHERMIC EX-VIVO PERFUSION OF THE PANCREAS

Abstract: a normothermic machine perfusion method for a pancreas is provided. first, a perfusate contained in a venous reservoir may be oxygenated such that a ratio of oxygen to carbon dioxide in the oxygenated perfusate is approximately 90%/10%. a first portion of the oxygenated perfusate may be pumped from the venous reservoir, through a dialysis filter, and back to the venous reservoir. a dialysate comprising a salt and glucose may be infused into the first portion of the oxygenated perfusate as the first portion is pumped through the dialysis filter. a concentration of glucose in the dialysate may be less than 8 mmol/l. a second portion of the oxygenated perfusate may be pumped through an arterial filter and through a pancreas graft. venous outflow from the pancreas graft may then be pumped to the venous reservoir.

Inventor(s): Trevor William REICHMAN, Justin MANUEL, Catherine PARMENTIER DE LEÓN, Samrat RAY, Markus SELZNER, Laura Ioana MAZILESCU, Sujani GAVASCGAR

CPC Classification: A01N1/143 (PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff ); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms ); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS)

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