Heparanase Inhibition for Graft Protection

Abstract: methods are provided for preparing and treating graft tissue, such as a solid organ, for example a lung, comprising contacting the graft tissue with protective amounts of a heparanase inhibitor prior to and/or after transplantation of the graft tissue. graft tissue, such as lung tissue prepared by the method also are provided. methods are provided for transplanting graft tissue, such as a solid organ, for example a lung, comprising contacting the graft tissue with protective amounts of a heparanase inhibitor prior to and/or after transplantation of the graft tissue.

Inventor(s): Pablo Gerardo Sanchez, Kentaro Noda

CPC Classification: A01N1/126 (PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff ); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms ); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS)

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