FABRICATION OF POLYMERIC MICRONEEDLES WITH HOLLOW AND POROUS TIPS VIA A SIMPLE MICROMOLDING PROCESS ASSISTED BY IONIC SALTS

Abstract: what is disclosed herein is a composition comprising a mixture of a soluble polymer in a solvent and an immiscible highly-soluble molecule in the same solvent, wherein the immiscible highly-soluble molecule substitutes inorganic ions, wherein the solubility of the immiscible highly-soluble molecule is more than 50 times higher than the solubility of the soluble polymer in the solvent, and wherein the soluble polymer can be cross linked to become insoluble during a material fabrication process. also disclosed is a method of making the composition, a microneedle comprising the composition, methods for making a silk protein nanostructure array, and silk protein nanostructure arrays.

Inventor(s): Benedetto MARELLI, Doyoon KIM, Hui SUN, Yunteng CAO

CPC Classification: A61M37/0015 ({by using microneedles})

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