CANCER TREATMENT WITH ANTI-CLAUDIN 18.2 ADC

Abstract: provided herein is a method of treating cancer in a human subject, comprising administering to the subject an antibody-drug conjugate (adc) comprising an antibody or antigen-binding fragment thereof which specifically binds human claudin 18.2 and monomethyl auristatin e, wherein the subject is administered at least one dose of the adc of about 0.3 to about 3.4 mg/kg.

Inventor(s): Bo CHEN, Wei LIU, Chaohong HU

CPC Classification: A61K47/6851 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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