20250195675. New Antibody-d (Heidelberg Pharma Research)
NEW ANTIBODY-DRUG CONJUGATE AS WELL AS METHODS OF PRODUCTION AND USES THEREOF
Abstract: the present disclosure relates to new antibody-drug-conjugates (adcs) comprising a favorable modular linker linking the pharmaceutically active drug substance with the antibody. the present disclosure further relates to methods of producing the antibody-drug conjugate as well as to uses thereof and pharmaceutical compositions comprising the same. embodiments of the present disclosure have been particularly developed as antibody-drug conjugates for use in the treatment of guanylate cyclase 2c (gucy2c)-positive gastrointestinal cancers and will be described hereinafter with reference to this application. however, it will be appreciated that the present disclosure is not limited to this particular field of use.
Inventor(s): Christoph Mueller, Hendrik Gruss, Torsten Hechler, Anik贸 P谩lfi, Marisa Schmitt
CPC Classification: A61K47/68037 ({Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates})
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