IMMUNOSTIMULATORY COMPOSITIONS AND METHODS OF USE THEREOF

Abstract: lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. the lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. the conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.

Inventor(s): Darrell IRVINE, Haipeng Liu

CPC Classification: A61K47/645 (Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers ))

Search for rejections for patent application number 20250195674