COMPOSITIONS AND METHODS FOR SELECTIVE DEPLETION OF TARGET MOLECULES

Abstract: described herein are compositions and methods for selective depletion of target molecules using a recyclable cdp-receptor-binding mediated complex to elicit endocytosis and cellular degradation of the target. exemplary compositions containing a peptide, such as a cdp peptide, that bind a transferrin receptor can be linked to a peptide that binds a target molecule. such compositions can be used to selectively recruit the target molecule to endosomes via transferrin receptor-mediated endocytosis of the composition and the bound target molecule. once inside the endosome, the acidic ph can lead to release of the target molecule from the composition due to ph-dependent binding of the composition for the target molecule, and the transferrin receptor portion is recycled back to the cell surface for “reloading”. the target molecule can then be trafficked into lysosomes wherein it is degraded.

Inventor(s): Zachary CROOK, James OLSON, Roland K. STRONG, Natalie Winblade NAIRN, Stephen TAPSCOTT, Kenneth GRABSTEIN

CPC Classification: A61K47/64 (Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers ))

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