MULTIFUNCTIONAL NATURAL KILLER (NK) CELL ENGAGER COMBINATION THERAPY FOR TREATING HEMATOLOGICAL NEOPLASTIC DISORDERS

Abstract: the present disclosure relates to methods for treating or preventing a leukemia or a myelodysplastic syndrome in a subject in need thereof, said method comprising administering to the subject an effective amount of a combination comprising: (i) a binding protein comprising a first antigen binding domain (abd) with binding specificity to cd123 and a second (abd) with binding specificity to nkp46; and one or both of: (ii) a bcl-2 inhibitor, and (iii) a dna hypomethylating agent.

Inventor(s): Giovanni ABBADESSA, Marielle CHIRON, Paula FRAENKEL, Angela VIRONE-ODDOS

CPC Classification: A61K40/15 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

Search for rejections for patent application number 20250195653