TRANSPLANTATION OF MITOCHONDRIA INTO LYMPHOID ORGAN AND COMPOSITION THEREFOR

Abstract: provided herein are a method for isolation and transplantation of intact mitochondria to a lymphoid organ (a primary lymphoid tissue or a secondary lymphoid tissue), a composition of cells prepared by using a method described herein, and a method for manufacturing cells described herein. in particular, provided herein are methods of isolating intact mitochondria from a donor cell. also provided herein are methods of transplanting mitochondria into a recipient cell. in some aspects, the methods can be performed in vivo. further provided are a composition of cells that include the cells prepared using the methods of the present invention.

Inventor(s): Masashi SUGANUMA, Hideyoshi HARASHIMA, Yuma YAMADA, Daisuke SASAKI, Takafumi YOKOTA

CPC Classification: A61K35/15 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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