COMPOSITIONS AND METHODS OF TREATMENT FOR CONGENITAL DIARRHEAL DISORDER

Abstract: in one aspect, the disclosure relates to pharmaceutical compositions containing lpar5 agonists including, but not limited to, compounds and methods for treating diseases and disorders associated with a mutation in myosin vb (myo5b), decreased lysophosphatidic acid receptor 5 (lpar5) expression, or both using the same. in one embodiment, the disclosed compositions and kits may be particularly useful in treating microvillus inclusion disease (mvid) and the diarrhea and malabsorption associated with the same. this abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Inventor(s): Izumi KAJI, James R. GOLDENRING

CPC Classification: A61K31/662 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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