APPLICATION OF TETRACYCLIC COMPOUND IN TREATMENT OF TUMORS

Abstract: the present invention relates to an application of a tetracyclic compound in the treatment of tumors. specifically provided is a use of a compound of formula i, an optical isomer or racemate thereof, a solvate thereof, a pharmaceutically acceptable salt thereof or a deuterated compound thereof, which is used for preparing a composition or a formulation, said composition or formulation being used for preventing and/or treating tumors. a compound of the invention has a uniquely advantageous precision treatment effect on tumors having low expression or no expression of the nnmt gene, high expression of a dna methylase, high expression of uhrfi, a high nnmt gene nucleotide site methylation level, and/or a high nnmt gene region dna cpg site methylation level.

Inventor(s): Yufeng SHI, Wenjiang MA

CPC Classification: A61K31/4745 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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