CXCR4/CXCR7 Blockade and Treatment of Human Papilloma Virus-Associated Disease

Abstract: the present invention relates to methods and compositions for treating human papilloma virus (hpv)-associated diseases using an inhibitor of cxcl12 signaling. the invention further relates to methods and compositions for treating immune checkpoint blockade resistant diseases using an inhibitor of cxcl12 signaling. the invention further relates to methods and compositions for enhancing the immune response against an hpv-associated disease using an inhibitor of cxcl12 signaling.

Inventor(s): Mark C. Poznansky, Jeffrey Gelfand, Sara Pai

CPC Classification: A61K31/395 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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