BIODEGRADABLE CONTROLLED RELEASE ANTIVIRAL AGENT IMPLANTS

Abstract: biodegradable controlled release agent implants and methods of making and using thereof, are preferably formed of poly(�-pentadecalactone-co-p-dioxanone) [poly(pdl-co-do)] or poly(ethylene brassylate-co-dioxanone), a family of polyester copolymers that degrade slowly in the presence of water. the material is suitable as the basis of a biodegradable controlled agent release implant that provides sustained release of a therapeutic such as an antiviral, thereby significantly increasing patent compliance and efficacy. results show long term co-administration of agents having greater than additive efficacy. the implant may be inserted subcutaneously, allowing degradation over a period of up to about 18 or 24 months, eliminating the need for removal by a trained practitioner.

Inventor(s): W. Mark Saltzman, Jagadish Beloor, Shalley N. Kudalkar, Karen S. Anderson, Fan Yang, Gina Buzzelli, Jinal Pothupitiya, Priti Kumar

CPC Classification: A61K9/0024 (Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations ; preparations containing radioactive substances )})

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