BEAD-BASED ASSAY TO SCREEN FOR INHIBITOR PROTEIN-GLYCAN INTERACTIONS IN NEURODEGENERATION

Abstract: a bead-based assay system and methods for screening molecule inhibitors of protein-glycan interactions. the assay system includes at least one donor bead and at least one acceptor bead. a first molecule is coupled to the at least one donor bead. the first molecule comprises a protein. a second molecule is coupled to the at least one acceptor bead. the second molecule comprises a glycan. the bead-based assay system includes a screening molecule to be screened for inhibiting protein-glycan interactions. the screening molecule is enabled to interact at a protein-glycan interface of the first molecule and the second molecule.

Inventor(s): Shannon Faris, Chunyu Wang

CPC Classification: G01N33/6845 ({Methods of identifying protein-protein interactions in protein mixtures})

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