CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY

Abstract: there is provided an oligonucleotide or a pharmaceutically acceptable salt thereof with a novel chemical modification pattern, which has a rna interfering action and/or a gene expression suppressing action. a sense strand region has a specific modification pattern with a 3′-modified nucleoside, and an antisense strand region has, in a specific region, a modification pattern in which dna, rna, 2′-o,4′-c-bridging-modified nucleosides, 2′-moe rna or the like are appropriately combined.

Inventor(s): Makoto KOIZUMI, Takao SHOJI, Taichi FUKUNAGA

CPC Classification: C12N15/1138 ({against receptors or cell surface proteins})

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