COMPOSITIONS AND METHODS FOR INTERNALIZING ENZYMES

Abstract: compositions and methods for treating lysosomal storage diseases are disclosed. biotherapeutic complexes containing an internalization effector binding domain and a lysosomal replacement enzyme activity are disclosed. the biotherapeutic complexes are capable of entering cells, segregating to the lysosome, and delivering the replacement enzyme activity to the lysosome.

Inventor(s): Andrew Baik, Katherine Cygnar

CPC Classification: C12N9/2402 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

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