NK CELLS TRANSFECTED WITH CAR RNA-LNP

Abstract: the present invention provides car mrna embedded to lipid nanoparticles to transfect immune nk cells and generate functional car-nk cells. the car-nk cells target tumor antigens to kill tumors. the present invention provides several advantages: transient expression, less toxicity and lower manufacturing cost for car-nk cells.

Inventor(s): Lijun Wu, Vita Golubovskaya

CPC Classification: C12N5/0646 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

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