HUMAN ANTIBODIES AGAINST ACTIVATED PROTEIN C AND USES THEREOF

Abstract: the present invention provides antibodies against activated protein c (apc). certain disclosed antibodies inhibit the anticoagulant activity of apc while preserving its beneficial cytoprotective functions. the present invention also provides nucleic acids, vectors, and host cells for producing the antibodies disclosed herein, as well as methods of using the antibodies to treat medical conditions such as bleeding, sepsis, and inflammation.

Inventor(s): Terry HERMISTON, Maxine BAUZON, Derek SIM, Douglas M. SCHNEIDER, Jan TEBBE, Oliver KENSCH, Ernst WEBER, Philipp ELLINGER, Katharina FILARSKY, Christoph MAHLERT, Bernardo MARTINS DA CUNHA ABECASIS, Inês Margarida CASTRO FERREIRA

CPC Classification: C07K16/40 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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