CD70 BINDING MOLECULES AND METHODS OF USE THEREOF

Abstract: the disclosure provides anti-cd70 antibodies, antigen binding fragments thereof, chimeric antigen receptors (cars) and engineered t cell receptors (tcrs) comprising an antigen binding molecule that specifically binds to cd70, polynucleotides encoding the same, and in vitro cells comprising the same. the polynucleotides, polypeptides, and in vitro cells described herein can be used in an engineered tcr and/or car t cell therapy for the treatment of a patient suffering from a cancer. in one embodiment, the polynucleotides, polypeptides, and in vitro cells described herein can be used for the treatment of multiple myeloma.

Inventor(s): Ruben Alvarez Rodriguez, Armen Mardiros

CPC Classification: C07K16/2875 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

Search for rejections for patent application number 20250188177