A MULTIPLE ANTIGEN PRESENTING SYSTEM (MAPS)-BASED STAPHYLOCOCCUS AUREUS VACCINE COMPRISING B- AND T-CELL ANTIGENS, IMMUNOGENIC COMPOSITION, AND USES THEREOF

Abstract: the present embodiments provide for an (sa). multiple antigen presenting system (maps) immunogenic composition comprising an immunogenic polysaccharide which induces a b-cell and t-cell immune response, where at least one (sa) peptide or polypeptide antigen is associated to the immunogenic polysaccharide by complementary affinity molecules. the present sa-maps immunogenic composition herein generates an immune response in a subject, preferably an antibody response and a b-cell and/or t-cell response, and can comprise at least one b-cell sa antigen and at least one t-cell sa antigen, and can elicit both humoral and cellular immune responses to the immunogenic polysaccharide and one, or multiple sa antigens at the same time.

Inventor(s): Richard MALLEY, Yingjie LU, Fan ZHANG, Kristin MOFFITT

CPC Classification: C07K14/31 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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