20250188125. De Novo Design Pro (University of Washington)
De novo Design of Protein Switches
Abstract: disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.
Inventor(s): Robert A. LANGAN, Scott BOYKEN, David BAKER, Walter NOVAK, Marc Joseph LAJOIE, Alferdo QUIJANO RUBIO
CPC Classification: C07K14/001 ({by chemical synthesis})
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