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20250188123. Proteas (Regents of the University of Minnesota)

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PROTEASE INHIBITORS

Abstract: the invention provides a compound of formula (i): or a salt thereof, wherein r-r, x, y, and r-rhave any of the values described in the specification, as well as compositions comprising a compound of formula (i). the compounds are useful as caspase-2 inhibitors.

Inventor(s): Michael A. Walters, Karen Ashe, Dezhi Liao, Gurpreet Singh, Merlin Bresinsky, Alexander Hubmann, Steffen Pockes

CPC Classification: C07K7/06 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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