C-Terminal Peptide Modification

Abstract: a method for providing a cargo to a c-terminal end of a peptide comprises a first stage and a second stage, wherein the first stage comprises reacting the c-terminal end of the peptide with a first reactant in the presence of a first catalyst and first radiation to provide a first intermediate, wherein the first catalyst is configured to decarboxylate the c-terminal end of the peptide in the presence of the first radiation; and wherein the second stage comprises exposing the first intermediate to a second reactant.

Inventor(s): Rienk Eelkema, Mariano Macchione, Peggy Bohlaender

CPC Classification: C07K1/1077 ({by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids})

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