SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION

Abstract: the present invention relates to novel specific small molecule inhibitors that block kmt9 methyltransferase activity. in particular, the present invention is concerned with a compound of formula (i) wherein x, x, x, x, r, r, r, r, rand l are as defined herein. further, the present invention is concerned with a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula (i). the present invention also relates to a compound of formula (i) and a pharmaceutical composition comprising a compound of formula (i) for use in medicine. yet further, the present invention is concerned with a compound of formula (i) and a pharmaceutical composition comprising a compound of formula (i) for use as inhibitor of kmt9. finally, the present invention is concerned with a compound of formula (i), wherein x, x, x, x, r, r, r, r, rand l are as defined herein, for use in the treatment of cancer selected from the group as defined herein

Inventor(s): Roland Schüle, Sheng Wang, Eric Metzger, Manfred Jung, Sebastian Klein

CPC Classification: C07H19/167 (with ribosyl as the saccharide radical)

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