CARBORANE COMPOUNDS AND METHODS OF USE THEREOF

Abstract: disclosed herein are compounds comprising dicarba-closo-dodecaborane. the compounds can be, for example, estrogen receptor beta (er�) agonists. in some examples, the compounds can be selective er� agonists. also provided herein are methods of treating, preventing, or ameliorating cancer in a subject, suppressing tumor growth in a subject, treating an inflammatory disease in a subject, treating a neurodegenerative disease in a subject, treating a psychotropic disorder in a subject, or a combination thereof, by administering to a subject a therapeutically effective amount of one or more of the compounds or compositions described herein, or a pharmaceutically acceptable salt thereof.

Inventor(s): Christopher Charles COSS, Chad BENNETT, Tyler WILSON, Sandip VIBHUTE, Hanna RADOMSKA, Samuel KULP

CPC Classification: C07F5/027 (ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins ))

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