20250188084. Compounds Methods Mod (KRONOS BIO, .)

COMPOUNDS AND METHODS FOR MODULATING CDK9 ACTIVITY

Abstract: provided are heterobifunctional degrader compounds that bind with cyclin dependent kinase 9 (cdk9) and e3 ubiquitin ligase. also provided are methods of treating a subject for a cdk9-mediated disease by administering a therapeutically effective dose of a pharmaceutical composition including the heterobifunctional degrader.

Inventor(s): WES TROTTER, MARIUS POP, ZHIHUA MA, DAVID FREEMAN

CPC Classification: C07D487/04 (Ortho-condensed systems)

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