IMIDAZOLONYLQUINOLINE COMPOUNDS AND THERAPEUTIC USES THEREOF

Abstract: atropisomers, solid forms, salt forms and deuterated derivatives of the atm inhibitor 8-(1,3-dimethyl-1h-pyrazol-4-yl)-1-(3-fluoro-5-methoxypyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydroimidazo[4,5-c]quinolin-2-one as well as compositions thereof are useful in the inhibition, regulation and/or modulation of signal transduction by atm kinase. the stable atropisomers do not interconvert and are represented by the following formulae:

Inventor(s): Thomas Fuchss, Axel Becker, Holger Kubas, Ulrich Graedler

CPC Classification: C07D471/04 (Ortho-condensed systems)

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