NON-AROMATIC CYCLIC-PYRIMIDINE ANALOGS AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Abstract: the present invention relates to compounds of formula i: and pharmaceutically acceptable salts or prodrug thereof. the present invention also relates to compositions comprising at least one compound of formula i, and methods of using the compounds of formula i for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (glccer), glucosylsphingosine (glcsph) and/or other glucosylceramide-based glycosphingolipids (gsls).

Inventor(s): Shawn P. Walsh, Zheng Tan, Ling Tong, Yuriy Slutskyy, Santhosh Francis Neelamkavil, Weiguo Liu, Anthony Donofrio

CPC Classification: C07D401/14 (HETEROCYCLIC COMPOUNDS (macromolecular compounds ))

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