POLYNUCLEOTIDES CONTAINING A STABILIZING TAIL REGION

Abstract: the invention features polynucleotides encoding a polypeptide including a 3′-stabilizing region and having increased stability compared to wild-type polynucleotides.

Inventor(s): Gabor BUTORA, Andrew W. FRALEY, Edward John MIRACCO, Jennifer NELSON, Amy RHODEN SMITH, Matthew STANTON, Brian R. FRITZ

CPC Classification: A61K48/0066 (Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy)

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