COMPACT DRUG RESPONSIVE DOMAINS FOR REGULATION OF FUNCTION/ABUNDANCE AND DELIVERY OF POLYPEPTIDE PAYLOADS

Abstract: provided herein are engineered, regulatable polypeptides comprising a payload and a drug responsive domains (drd), wherein the drd is operably linked to the payload and wherein the drd is responsive to a ligand. the drd is optionally fkbp13, either wildtype or a variant thereof.

Inventor(s): Dhruv Kam Sethi, Jan ter Meulen, Dexue Sun, Kerri-Lynn Sheahan, Andres Alvarado

CPC Classification: A61K48/005 (Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy)

Search for rejections for patent application number 20250186614