DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF

Abstract: the present disclosure relates to targeting moieties such as peptides that can bind to dll3. the disclosure also provides targeting constructs, which may include a targeting moiety attached, via an optional linker, to a chelating agent for association of a cargo. methods of making the constructs and formulations thereof are also provided. methods of using the constructs and/or formulations thereof to treat subjects, for example, to treat or prevent cancer, are also described.

Inventor(s): Chunhui HUANG, III, Chester A. METCALF, Thomas C. BRUTON, Zhong MA, Lihua WU, Roberto COSTANTE, Danila BRANCA, Federica ROSOLIA, Alonso RICARDO

CPC Classification: A61K38/12 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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