ONCOLYTIC VIRUS COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER

Abstract: provided herein, inter alia, are oncolytic viruses that express recombinant proteins having bispecific activity. the recombinant proteins include a first fusion protein comprising a first fc domain covalently linked to a chemokine domain, and a second fc fusion protein comprising a second fc domain covalently linked to an anticancer therapeutic antibody domain. the recombinant proteins and oncolytic viruses provided herein are contemplated to be effective for the treatment of cancer, particularly by trafficking immune cells to the tumor microenvironment.

Inventor(s): Jianhua Yu, Michael A. Caligiuri, Lei Tian

CPC Classification: A61K35/763 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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