COMBINATION THERAPIES COMPRISING A SOS1 INHIBITOR AND A MEK INHIBITOR

Abstract: the present invention relates to combination therapies for treating cancers associated with genetic alterations of the mapk pathway and/or egfr. in particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a sos1 inhibitor and mek inhibitor, pharmaceutical compositions comprising a such compositions, kits comprising such compositions and methods of use therefor.

Inventor(s): Jacob Haling, Shilpi Khare

CPC Classification: A61K31/5377 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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