METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME

Abstract: the present invention features a method of reducing tactile dysfunction or anxiety in a subject diagnosed with autism spectrum disorder, rett syndrome, or fragile x syndrome by administering a gabaagent having reduced blood brain barrier or by expressing a nucleic acid encoding an exogenous alpha or beta subunit of a gabareceptor in dorsal root ganglion neurons in the subject using a vector.

Inventor(s): Lauren L. Orefice, David D. Ginty

CPC Classification: A61K31/495 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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