ISOLATION AND DIAGNOSTIC METHODS USING CELL TYPE-SPECIFIC AND/OR ORGAN-SPECIFIC EXTRACELLULAR VESICLE (EV) MARKERS

Abstract: the present invention relates to novel biomarkers and combinations thereof for cell type-specific and/or organ-specific extracellular vesicles, in particular, brain-specific and/or neuron-specific extracellular vesicles. the present invention also provides methods for isolation and/or enrichment of cell type-specific and/or organ-specific extracellular vesicles, methods for identification of extracellular vesicles derived from a cell, and methods for diagnosing or prognosing a disorder, e.g., a neurodegenerative disorder, using the cell type specific and/or organ-specific extracellular vesicles. compositions in the form of kits of reagents for detecting the cell type-specific and/or organ-specific extracellular vesicles are also provided.

Inventor(s): Dmitry Ter-Ovanesyan, Siddharth Iyer, George M. Church, David R. Walt

CPC Classification: G01N33/6896 ({Neurological disorders, e.g. Alzheimer's disease})

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