20250180577. Protein Sequenci (Glyphic Biotechnologies, .)
PROTEIN SEQUENCING VIA COUPLING OF POLYMERIZABLE MOLECULES
Abstract: provided herein are methods and systems for sequencing proteins. one or more methods disclosed herein may use linkers comprising an amino acid-reactive group and an additional reactive moiety that may be used to couple a polymerizable molecule. the linker may couple to a polymerizable molecule and an amino acid of a peptide and a capture moiety via the polymerizable molecule, followed by cleavage of the amino acid from the peptide. further processing and analysis may be conducted using, for example, nanopores or nanogaps.
Inventor(s): Asmamaw WASSIE, Daniel Masao ESTANDIAN, Andrew John PRICE, Boyang HUA, Joshua Young Cynming YANG, David DODD, Gerardo Fabian DELGADO, Elaine Jean SU
CPC Classification: G01N33/6818 ({Sequencing of polypeptides})
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- Patent Applications
- Glyphic Biotechnologies, Inc.
- CPC G01N33/6818
- Asmamaw WASSIE of Leander TX US
- Daniel Masao ESTANDIAN of Antioch CA US
- Andrew John PRICE of San Mateo CA US
- Boyang HUA of Oakland CA US
- Joshua Young Cynming YANG of Richardson TX US
- David DODD of San Francisco CA US
- Gerardo Fabian DELGADO of Oakland CA US
- Elaine Jean SU of Martinez CA US