SURFACED MODIFICATION OF NALNF4 NANOPARTICLES WITH BISPHOSPHONATE DERIVATIVES FOR MASS CYTOMETRY APPLICATIONS

Abstract: described herein are nanoparticles comprising nalnf4, wherein ln includes all non-radioactive lanthanide elements, or nayf4, and methods of making and using the same. the nanoparticles may optionally be modified with peg or zwitterionic polymers containing a bisphosphonate end group, wherein the bisphosphonate end group optionally comprises an aminohexyl group. as described herein. nalnf4 or nayf4 nanoparticles may be used as high-sensitivity reagents for mass cytometry.

Inventor(s): Mahtab Abtahi, Daniel Majonis, Ladan Gheiratmand, Hyungjun Cho, Loryn P. Arnett, Mitchell A. Winnik

CPC Classification: G01N33/587 ({Nanoparticles})

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