METHODS AND MATERIALS FOR THE DETECTION OF LATENT TUBERCULOSIS INFECTION

Abstract: there are provided methods of method of determining the latent tuberculosis (tb) infection status in an individual comprising: (i) providing a sample comprising t-cells; (ii) exposing the sample of (i) to one or more tb antigens; (iii) identifying t-cells in the sample that are cd4 positive and secrete ifn-� in response to tb antigens; (iv) identifying those cells of (iii) which are also hla-dr positive; and optionally (v) calculating the cells identified in (iv) as a percentage of those identified in (iii); wherein the identification of cells in (iv) and/or the percentage of cells calculated in (v) correlates to latent tb infection status of the individual, and wherein steps (iii) and (iv) can be carried out either sequentially or simultaneously. there are also provided compositions and kits for use in such methods.

Inventor(s): Ajit Lalvani, Alice Halliday

CPC Classification: G01N33/56972 (for microorganisms, e.g. protozoa, bacteria, viruses)

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