CRISPR-AID USING CATALYTICALLY INACTIVE RNA-GUIDED ENDONUCLEASE

Abstract: the present invention relates to nucleobase editing complexes comprising a) a catalytically inactive rna-guided endonuclease having a sequence identity of at least 60% to seq id no: 126 or seq id no: 155 and b) a nucleobase editing domain, as well as polynucleotides encoding said nucleobase editing complexes, nucleic acid constructs and expression vectors comprising said polynucleotides, host cells comprising said nucleobase editing complexes and/or polynucleotides, and methods for preparing and using said nucleobase editing complexes.

Inventor(s): Takashi Nakanishi, Michael David Thomas

CPC Classification: C12N15/90 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

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