Spatially Localized Gene Delivery of Adeno-Associated Viruses

Abstract: a gene-targeting chimera including an adeno-associated virus (aav) and a nanoparticle is disclosed. the nanoparticle may include a silica shell coating. the aav and nanoparticle may be covalently attached using a linking chemistry. the nanoparticle may include a magnetic nanoparticle (mnp), a magnetic nanodisc (mnd), or a quantum dot (qd). the gene-targeting chimeras may retain the tropism of original aav serotype used. additionally, the gene-targeting chimeras may also be able to be controlled using a magnetic field. the gene-targeting chimeras may enable nanoparticle delivery to specific cells and organs.

Inventor(s): Polina Olegovna ANIKEEVA, Keisuke Nagao

CPC Classification: C12N15/86 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

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