SINGLE DOMAIN ANTIBODY LIBRARIES WITH MAXIMIZED ANTIBODY DEVELOPABILITY CHARACTERISTICS

Abstract: described here are vhh antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (cdrs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. the antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.

Inventor(s): Andrew Raymon Morton Bradbury, Andre A. Teixeira

CPC Classification: C12N15/1037 ({Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display})

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