20250179460. Human Alpha-galac (Crosswalk Therapeutics, .)
HUMAN ALPHA-GALACTOSIDASE VARIANTS
Abstract: engineered human alpha-galactosidase polypeptides and compositions thereof are provided. the engineered human alpha-galactosidase polypeptides have been optimized to provide improved thermostability, serum stability, improved cellular uptake, stability under both acidic (ph<4) and basic (ph>7) conditions, reduced immunogenicity, and improved globotriaosylceramide removal from cells. the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes are described.
Inventor(s): William Casey Hallows, Nikki Dellas, Yu Zhu, Judy Victoria Antonio VIDUYA, Chinping Chng, Antoinette Sero, Rachel Cathleen Botham, David William Homan, Moulay Hicham Alaoui Ismaili, Jonathan Vroom, Adam P. Silverman, Kristen Jean Vallieu, Charu Shukla Reddy, Kerryn McCluskie
CPC Classification: C12N9/2465 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))
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- Patent Applications
- Crosswalk Therapeutics, Inc.
- CPC C12N9/2465
- William Casey Hallows of San Francisco CA US
- Nikki Dellas of San Carlos CA US
- Yu Zhu of Newark CA US
- Judy Victoria Antonio VIDUYA of South San Francisco CA US
- Chinping Chng of Menlo Park CA US
- Antoinette Sero of Foster City CA US
- Rachel Cathleen Botham of Burlingame CA US
- David William Homan of San Ramon CA US
- Moulay Hicham Alaoui Ismaili of San Mataeo CA US
- Jonathan Vroom of San Francisco CA US
- Adam P. Silverman of San Carlos CA US
- Kristen Jean Vallieu of Union City CA US
- Charu Shukla Reddy of San Jose CA US
- Kerryn McCluskie of Pacifica CA US