LACHNOSPIRACEAE BACTERIUM ND2006 CAS12A MUTANT GENES AND POLYPEPTIDES ENCODED BY SAME

Abstract: this invention pertains to mutant lachnospiraceae bacterium nd2006 (lb) cas12a nucleic acids and proteins for use in crispr/cas12a endonuclease systems, and their methods of use. in particular, the invention pertains to an isolated mutant lbcas12a protein, wherein the isolated mutant lbcas12a protein is active in a crispr/cas12a endonuclease system. the invention also includes isolated nucleic acids encoding mutant lbcas12a proteins, ribonucleoprotein complexes and crispr/cas12a endonuclease systems having mutant lbcas12a proteins.

Inventor(s): Sarah Franz BEAUDOIN, Michael Allen COLLINGWOOD, Christopher Anthony VAKULSKAS

CPC Classification: C12N9/22 (MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media ))

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