CYCLODEXTRIN DIMERS, COMPOSITIONS THEREOF, AND USES THEREOF

Abstract: a new class of synthetic cyclodextrin dimers is described. exemplary cyclodextrin dimers can treat atherosclerotic plaques by targeting various forms cholesterol both intracellularly and extracellularly. also provided are methods of depleting atherosclerotic plaques of cholesterol, cholesterol esters, 7-ketocholesterol and 7-ketocholesterol esters by treatment with such cyclodextrins. further described are subclasses of dimers that have high specificity for 7-ketocholesterol.

Inventor(s): Matthew S. O'CONNOR, Milo Malanga, Michael Kope, Christina A.T.M.B. Tom, Amelia M. Anderson

CPC Classification: C08B37/0012 (Preparation of polysaccharides not provided for in groups - ; Derivatives thereof (cellulose ; {microbiological processes }))

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