ANTIBODIES WITH FC MODIFICATIONS AND METHODS OF USING THE SAME

Abstract: the disclosure features anti-tumor necrosis factor receptor superfamily (tnfrsf), anti-tumor necrosis factor superfamily (tnfsf), anti-cd28, and anti-icos antibodies and antigen-binding fragments thereof with amino acid modifications at the fc domain, and the use of these antibodies or antigen-binding fragments to modulate immune response. the antibodies and antigen-binding fragments thereof can be used to treat a wide variety of cancers, autoimmune disorders, neurological disorders, infectious diseases, inflammatory diseases, and transplant rejections.

Inventor(s): Denise L. FAUSTMAN

CPC Classification: C07K16/2878 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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